How Do Cell Types Shape Human Cognition?

Despite unprecedented insights into the brain's composition we still do not understand how cellular activity organizes at the circuit level and bridges to cognitive computations. This challenge is particularly acute in humans, where we lack the tools to establish causal links between cell types and brain computations. How do human neurons of all flavors combine to produce cognition? What principles underly such computations? Can these computations be reverse-engineered and simulated from first principles?

We develop tools to unravel causal links in human microcircuit dynamics and cognition in health and disease. To do so, we adopt a multidisciplinary approach combining biophysics, statistical learning, optimization, computational simulation, and biophysics-informed AI.